Circulatory Histology Slides
RED BLOOD CELLS
Red blood cells (erythrocytes) aid in delivering oxygen to body tissues through the circulatory system.
Neutrophils are considered the most abundant of all WBCs. They are 9-12Âµm in diameter. They usually have a divided nucleus that separate into 2-5 lobes. Neutrophils are also considered phagocyte and generally found in the blood stream. They are the first to respond to the site of injury in matter of minutes.
Eosinophils are comprised less than five percent of all white blood cells. They range from 10-14Âµm in diameter. Eosinophils differ to other WBCs is that they have two-lobed nucleus. They are developed and matured within the bone marrow before migrating into the blood. Eosinophils primary functions are fighting parasitic infections.
Basophils are rare in the blood comprising less than one percent of all white blood cells. They are 8-10Âµm in diameter. Basophils have prominent dark-purple cytoplasmic granules that usually make an S-shaped nucleus. The granules contain histamine and heparin. Thus are usually activated in response in immunologically mediated hypersensitivity allergic reactions.
Lymphocytes comprises 20% to 25% of all WBCs. They range from 8-10Âµm in diameter. Lympocytes have a large round nucleus that fills most of the cell. There are three types of lymphocytes: T cells, B cells, and NK cells.
Monocytes are considered the largest and most comprised of all WBCs. They range from 12-15Âµm in diameter. They have a bluish cytoplasm with a kidney-bean shaped nucleus. When fully matured in the bone marrow, monocytes entered the bloodstream to differentiate into either macrophages or dendritic cells.
Platelets are small disk-shaped cell fragments that are involved in clotting process. Platelets are 2-3Âµm in diameter.
Reticulocytes do not have a cell nucleus. Reticulocytes are immature red blood cells that formed in the red bone marrow. Once formed in the bone marrow they circulate through the blood stream for about a day before developing into mature red blood cells. As you can see in the photo, the dark-purple is the mesh-like ribosomal RNA.
Arterial clot formation is an important protective seal over an injury.
CHRONIC MYELOGENOUS LEUKEMIA
Chronic myelogenous leukemia (CML) is an uncommon cancer of white blood cells that occurs inside the bone marrow. CML is characterized to have an increased and unregulated growth of myeloid cells in the bone marrow. Generally older adults typically get CML and rarely occur in children though it can occur at any age.
CHRONIC LYMPHOCYTIC LEUKEMIA
Chronic lymphocytic leukemia (CLL) is an abnormal B-cell lymphocytes that is the second most common adulthood leukemias. Abnormal lymphocytes do not become healthy WBCs which are unable to fight off infections. They tend to increase in the blood stream making it impossible for healthy white cells to fight off infections.
HEMOLYTIC DISEASE OF THE NEWBORN
Hemolytic disease in fetus or newborn is caused when the mothers antibodies (Rh blood group) is incompatible to the offspring.. In severe hemolytic disease cases causes anemia and possible heart failure. In less severe cases, cause jaundice and could possible lead to brain damage if left untreated.
SICKLE CELL ANEMIA
Sickle cell anemia is a blood disorder causing the red blood cells to have an abnormal crescent sickle shape. Sickle cell anemia is caused by a mutation in the hemoglobin gene.